Clark is best known for hosting long-running television shows such as "American Bandstand," the game show "Pyramid" and "Dick Clark's New Year's Rockin' Eve."
He was nicknamed "America's oldest teenager" and maintained his youthful looks into his 70s.
Clark had been in St. John's Hospital in Santa Monica, Calif., after undergoing an outpatient procedure Tuesday night. He suffered the heart attack following the procedure and attempts to resuscitate him were unsuccessful.
Clark is survived by his wife, Kari, and his three children.
Clark, who started out as a TV announcer in Utica, New York, parlayed his "Bandstand" fame into a career as a producer and host of dozens of other shows, including ABC's annual New Year's Eve telecast, which he launched in 1972.
With his clean-cut image and youthful appearance, he presided over more than three decades of pop music and dance trends as host of "American Bandstand," the first network TV show to feature rock 'n' roll.
He also produced such perennial TV events as the American Music Awards and the Golden Globes telecast.
Musicians, entertainers and fans of all ages quickly took to Twitter to remember Clark.
"American Idol" host Ryan Seacrest, who began co-hosting "New Year's Rockin' Eve" in 2005, tweeted, "I am deeply saddened by the loss of my dear friend Dick Clark. He has truly been one of the greatest influences in my life. My thoughts and prayers are with his family."
"REST IN PEACE to the DICK CLARK!! U were pioneer n a good man!! Thank u sir" wrote Snoop Dogg.
And Isaac Hanson of the band Hanson tweeted, "Dick Clark was a Rock 'n' Roll Radio/TV icon with an influence on pop culture for more than 50 years. Rest in peace."
Comedian Joan Rivers tweeted, "Very sad to hear about Dick Clark. What a great life. What a great career. Relevant until the end. He will be missed!"